Pattern of c-Fos expression induced by tail suspension test in the mouse brain
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منابع مشابه
Pattern of c-Fos expression induced by tail suspension test in the mouse brain
The tail suspension test (TST) has been widely used as a screening assay for antidepressant drugs. However, the neural substrates underlying the stress response and antidepressant-like effect during the TST remain largely unknown despite the prevalence of this test. In the present study, we used immunohistochemistry to examine alterations in c-Fos expression as a measure of neuronal activity in...
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Most classical preclinical tests to predict antidepressant activity were initially developed to detect compounds that influenced noradrenergic and/or serotonergic activity, in accordance with the monoaminergic hypothesis of depression. However, central opioid systems are also known to influence the pathophysiology of depression. While the tail suspension test (TST) is very sensitive to several ...
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ژورنال
عنوان ژورنال: Heliyon
سال: 2017
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2017.e00316